NCKU | Taiwan
Dr. Jiann-Ruey Hong is a molecular virologist known for foundational contributions to fish virology, host–pathogen interactions, and programmed cell death mechanisms in aquatic species. His work has significantly advanced understanding of betanodavirus biology, viral modulation of mitochondrial pathways, and apoptosis–necrosis transitions during infection. He has extensively investigated Bcl-2 family regulators, ER-stress responses, cytokine signaling, and interferon-mediated antiviral immunity using zebrafish and fish cell models. Dr. Hong’s research has revealed how viral proteins such as B1, B2, VP3, and α-protein orchestrate mitochondrial dysfunction, energy collapse, and host survival factor suppression. His publications in high-impact journals span molecular virology, immunology, developmental biology, and aquaculture biotechnology. He has served in numerous editorial roles across international journals in virology, oncology, molecular biology, and biotechnology, demonstrating sustained influence on scholarly communication. His expertise is widely recognized through invitations as a speaker at global scientific meetings and participation in scientific committees. Dr. Hong has contributed as a reviewer for a broad spectrum of journals in virology, immunology, aquaculture, molecular medicine, and cellular biology. His work has been acknowledged by multiple international biographical listings, research recognitions, and awards celebrating excellence in virology. He has supported student advancement through mentorship and participation in academic evaluation panels. His editorial leadership includes guiding special issues focused on viral infection, autophagy, and molecular symmetry in host–virus dynamics. As an active member of professional societies in virology, marine biotechnology, and cell death research, he continues to shape the field’s scientific direction. His research vision integrates molecular signaling, viral pathogenesis, and host defense to improve aquaculture health strategies. He remains a driving force in uncovering the cellular mechanisms underlying viral neuropathogenesis in marine organisms. His scholarship has also contributed to broader biomedical insights relevant to apoptosis regulation and mitochondrial biology. Through sustained scientific service, editorial contributions, and innovative research, Dr. Hong stands as a prominent figure in contemporary molecular virology.
Publications
DHA affects ISKNV-induced autophagy flux via the AMPK/mTOR/ULK1 and BECN1/SQSTM1 axes, limiting viral replication in fish cells. Fish and Shellfish Immunology.
Enhancement of reactive oxygen species metabolism by antioxidant enzyme Cu/Zn-SOD can block betanodavirus-induced necroptosis and suppress viral replication in fish cells. Fish and Shellfish Immunology.
ISKNV triggers AMPK/mTOR-mediated autophagy signaling through oxidative stress, inducing antioxidant enzyme expression and enhancing viral replication in GF-1 cells. Viruses.
A mitochondrion-targeting protein (B2) primes ROS/Nrf2-mediated stress signals, triggering apoptosis and necroptosis in lung cancer. Biomedicines.
Infectious spleen and kidney necrosis virus induces the reactive oxidative species/Nrf2-mediated oxidative stress response for the regulation of mitochondrion-mediated Bax/Bak cell death signals in GF-1 cells. Frontiers in Microbiology.