Assoc. Prof. Halil İbrahim Güler is a distinguished molecular biologist and geneticist whose research unites enzymology, proteomics, bioinformatics, and microbial genetics. A graduate of Sivas Cumhuriyet University and Karadeniz Technical University (KTÜ), where he also earned his Ph.D., Güler’s early studies on Thermus plasmids laid the foundation for his focus on microbial adaptation and enzyme mechanisms. Currently serving as Associate Professor in KTÜ’s Department of Molecular Biology and Genetics, he leads innovative research on microbial enzymes—particularly β-glucosidases—and designs biocatalysts for industrial and medical applications. Using structural modeling, molecular docking, and dynamics simulations, he explores enzyme-ligand interactions and develops compounds with antitumor, antidiabetic, and anti-Alzheimer potential. His prolific publications highlight contributions to biocatalyst design, protein stability, and natural product biosynthesis. As an educator and mentor, he teaches courses in Bioinformatics, Microbial Ecology, and Gene Manipulation, fostering data-driven and experimental proficiency among students. His administrative roles and participation in research committees reflect his dedication to institutional growth and scientific collaboration. Through his academic leadership and interdisciplinary research, Güler continues to advance molecular genetics and biotechnology in Turkey and beyond.
Publications
Synthesis, characterization and antitumor assessments of sulfonamide-1,2,4-triazole compounds with EGFR inhibitory potential: DFT calculation, molecular docking, molecular dynamics, and MM/PBSA approaches. (2026). Journal of Molecular Structure.
Comparison of active site mutations at subsite +2 of Anoxybacillus ayderensis A9 β-glucosidase for hydrolysis of pNPG and polydatin. (2025). BMC Biotechnology.
New methyl/benzyl-1,2,4-triazole-3-one derivatives: Synthesis, characterization (IR, NMR), antidiabetic, anti-Alzheimer, and molecular docking study. (2025). Journal of Biochemical and Molecular Toxicology.
Fluorobenzylidene-1,2,4-triazol-3-one derivatives: Synthesis, characterization, antimicrobial activity, and molecular docking study. (2025). Russian Journal of Organic Chemistry.
Biochemical characterization of a novel, glucose-tolerant β-glucosidase from Jiangella ureilytica KC603, and determination of resveratrol production capacity from polydatin.