Published on by Computational Biologists

Mr. Hongwei Liu | Lentiviral vector-mediated gene therapy | Young Scientist Award 

University of Electronic Science and Technology | China

Hongwei Liu is a biomedical engineering researcher whose work focuses on advancing gene therapy through innovative vector design and molecular engineering. His expertise spans tissue engineering, cellular and molecular biology, bioinformatics, CRISPR/Cas9 gene editing, molecular cloning, cell reprogramming, and biomaterial-based delivery systems. He has made significant contributions to the development of next-generation lentiviral vectors, particularly erythroid-specific β-globin constructs designed to enhance therapeutic outcomes for β-thalassemia. His research includes preclinical evaluation of lentiviral vector-mediated gene correction in disease models, demonstrating that partial hematopoietic stem cell modification and reduced-intensity conditioning can achieve reliable engraftment and phenotype restoration. With multiple first-author and co-authored publications in reputable scientific journals, his work reflects a strong commitment to integrating engineering principles with clinical translational goals. His contributions play an important role in shaping emerging strategies in gene delivery, precision genome engineering, and the development of safer, more effective treatments for genetic disorders. He continues to explore novel delivery platforms that improve therapeutic efficiency while minimizing risk. His work also emphasizes data-driven optimization of vector integration to enhance safety profiles. Through ongoing innovation and rigorous research, he is contributing to the future of personalized and regenerative medicine. He remains focused on advancing therapeutic technologies that address unmet clinical needs. His research vision aligns with creating scalable gene-based solutions for complex diseases. His work is steadily strengthening the scientific foundation for next-generation molecular therapies.

Profile: Scopus

Publications

Fatigue cracking criterion induced by defects in high-strength steel
Author, A., Author, B., Author, C., & Author, D. (2026). Fatigue cracking criterion induced by defects in high-strength steel. Journal of Materials Science and Technology.

Characterization of the Carbides in Carburized CSS-42L Steel and Their Effect on the Fatigue Failure Mechanism
Author, A., Author, B., Author, C., Author, D., & Author, E. (2025). Characterization of the carbides in carburized CSS-42L steel and their effect on the fatigue failure mechanism. Metals.

 A Novel Model for the Relationship Between Microstructures and Strength in Lath Martensite Steels
Author, A., Author, B., Author, C., & Author, D. (2025). A novel model for the relationship between microstructures and strength in lath martensite steels. Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science.

 Revisiting the effect of localized alloying elements on stacking fault energy in austenitic steel
Author, A., Author, B., Author, C., & Author, D. (2025). Revisiting the effect of localized alloying elements on stacking fault energy in austenitic steel. Materials Science and Engineering A.

 Multiscale microstructure evolution and its influencing mechanism on yield strength and toughness of a newly high strength martensitic stainless bearing steel
Author, A., Author, B., Author, C., Author, D., & Author, E. (2025). Multiscale microstructure evolution and its influencing mechanism on yield strength and toughness of a newly high strength martensitic stainless bearing steel.

 

 

Mr. Hongwei Liu | Lentiviral vector-mediated gene therapy | Young Scientist Award

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