Dr. Karolina Stępień | Extracellular Matrix | Best Researcher Award
Medical University of Silesia | Poland
Dr. Karolina Stępień is a molecular biologist and medical scientist specializing in the extracellular matrix (ECM) and its role in connective tissue and vascular diseases, particularly abdominal aortic aneurysm (AAA). Her research explores the molecular architecture and remodeling of the ECM, focusing on collagens, elastin, metalloproteinases, and thrombospondins to understand vascular wall degeneration and identify biomarkers for prognosis and therapy. Beyond vascular pathology, she has contributed to studies on osteogenesis imperfecta and the potential of induced pluripotent stem cells (iPSCs) in gene therapy and regeneration, as well as on epithelial-mesenchymal transition (EMT) in pediatric craniopharyngioma as a predictor of tumor recurrence. Her work, published in leading journals such as International Journal of Molecular Sciences, Biomolecules, and Journal of Applied Genetics, advances knowledge of ECM-driven disease mechanisms and molecular medicine. As an educator at the Medical University of Silesia, she teaches molecular biology and genetics, integrating research and clinical application. Leading the “BIOMOLEK” Scientific Club, she mentors young researchers in ECM biology and molecular diagnostics. She actively participates in international scientific collaborations and conferences, strengthening the global exchange of knowledge in vascular and molecular pathology. Through her interdisciplinary research, teaching, and mentorship, Dr. Stępień continues to bridge fundamental molecular science with translational therapeutic innovation, shaping the future of biomedical research and education.
Profile: Orcid
Publications
Bajdak-Rusinek, K., Diak, N., Gutmajster, E., Fus-Kujawa, A., Stępień, K. L., Wójtowicz, W., Kalina, M., & Mandera, M. (2025). The EMT status in the primary tumor of adamantinomatous craniopharyngioma predicts postoperative recurrence in children. Child's Nervous System.
Stępień, K. L., Auguściak-Duma, A., Fus-Kujawa, A., Diak, N., Lesiak, M., Bogunia, E., Hermyt, M., Czekaj, P., Sznapka, M., & Ziaja, D., et al. (2025). Abdominal aortic aneurysm: Characteristics of extracellular matrix abnormalities caused by disorders of collagen types I and III and elastin. International Journal of Cardiology.
Stępień, K. L., & Sieroń, Ł. (2025). Zastosowanie komórkowych modeli 3D w badaniach macierzy zewnątrzkomórkowej wybranych chorób dziedzicznych i autoimmunologicznych. In Zagadnienia aktualnie poruszane przez młodych naukowców 24 (Book chapter).
Strzelec, K., Dziedzic-Kowalska, A., Sieroń, Ł., Bereta, G. P., Stępień, K. L., Ferenc, K., Łazarz-Bartyzel, K., Olszewska-Czyż, I., Rąpalska, I., & Aptekorz, M., et al. (2025). Polymorphic variants of peptidylarginine deiminase gene from P. gingivalis—Searching for targets for supportive therapy of periodontitis. International Journal of Molecular Sciences.
Stępień, K. L., Bajdak-Rusinek, K., Fus-Kujawa, A., Kuczmik, W., & Gawron, K. (2022). Role of extracellular matrix and inflammation in abdominal aortic aneurysm. International Journal of Molecular Sciences.
Stępień, K. L. (2022, May 25). Quantitative assessment of extracellular matrix proteins in the abdominal aortic aneurysm. International Medical Congress of Silesia 2022 (SIMC 2022) Conference Abstract, Katowice, Poland.